Case Studies Existing Human Tissue Repositories:Best Practic: Best Practices for a Biospecimen Resou
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How to build an integrated biobank: Preparedness for a natural disaster: Offering aggregate results to participants in genomic research: Beskow , Wylie Burke , Stephanie M. Fullerton , Richard R. Sharp Genetics in Medicine Biological sample collection and processing for molecular epidemiological studies.
- Core 2: Tissue Core | Chronic Lymphocytic Leukemia Research Consortium (CRC).
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The tissue microarray data exchange specification: A community-based, open source tool for sharing tissue microarray data Jules J. Berman , Mary E. Edgerton , Bruce A.
Case Studies of Existing Human Tissue Repositories
The surface antigen phenotype of each sample is determined by multiparameter flow cytometric analysis. Additional project-specific flow cytometry testing are performed on specific samples for hypothesis-driven studies as requested by the CRC investigators. The acquisition of this data occurs when the patient is first enrolled in the CRC and for all subsequent blood draws serial samples.
This standardized cytogenetics data provides accurate and uniform interphase FISH studies for CRC clinical trials and research investigators.
International Efforts to Develop Biospecimen Best Practices
The Tissue Core distributes specific banked and characterized samples to the CRC investigators for hypothesis-driven studies. The distribution of these characterized samples occurs when an investigator requests the number and type of samples required and completes a Sample Acquisition Form. This form requires a description of the proposed hypothesis, the outcome of the project, and the number and type of samples requested.
Other requested data such as clinical and demographic data also can be made available to the investigator via the electronic database. This trafficking and distribution of uniformly characterized CLL samples, with their associated surface phenotype, IgVH mutation status, cytogenetics, clinical, and demographic data, facilitates and expedites the CRC investigators in their studies of the biology and evolution of CLL.
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The resources generated by the Tissue Core include a large number of banked CLL samples from patients diagnosed at different institutions across the country. In addition, the basic set of data collected on each of these samples allows CRC investigators to retrieve desired samples for specific hypothesis-driven studies. The data on each sample including longitudinal time points on each patient comprises clinical data, demographic data, immunophenotyping, IgVH, karyotype, and data from the hypothesis-driven studies.
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This interactive information on each CLL sample allows CRC investigators and clinicians to better understand the biology of CLL and perform improved prognosis and clinical trials for this leukemia. Click here to view the resources generated by the Tissue Core are reflected in the publications by the CRC investigators.
Article Figures & Data
Best Practices for Repositories I: Case studies of existing human tissue repositories: National Cancer Institute, United States. Common minimum technical standards and protocols for biological resource centers dedicated to cancer research.
Best Practices” for a Biospecimen. Resource for the Genomic case studies of existing human tissue resources to evaluate their utility for genomics- and Although not widely done today, a best practice for repositories is to. "Best Practices" for a Biospecimen Resource for the Genomic and Proteomic Era has conducted case studies of twelve existing human tissue repositories to.
International Agency for Research on Cancer. OECD Best practice guidelines for biological resource centers. Organization for Economic Cooperation and Development.
Recommendation Rec 4 of the Committee of Ministers to member states on research on biological materials of human origin. Council of Europe Committee of Ministers. Case studies of existing human tissue repositories: UN Recommendations on the transport of dangerous goods model regulations.