DNA Topoisomerases in Cancer Therapy: Present and Future

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    What Is 4-Strand DNA & Why Are Scientists So Excited?

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    In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone. This volume commemorates the 30th anniversary of the discovery in of the first DNA topoisomerases, i.e topoisomerase I in E. coli, then provisionally.

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