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Cancer proteomics: from bench to bedside

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Cancer Proteomics From Bench to Bedside Cancer Drug Discovery and Development

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Chapters 6—8 provide specific examples of the use of proteomics in the study of renal cell carcinoma, lung cancer and acute leukaemia. Again there are informative backgrounds for the non-specialist reader and several interesting sections on tumour antigens, the importance of sample selection and preparation, molecular diagnosis and classification of cancer using proteomics, multiplexed immune-based protein assays and drug target validation using proteomics.

Chapter 9 is excellent and deals with practical aspects of tumour biomarker discovery; a must for all new researchers to the field, although would have been better placed earlier in the book. It describes guidelines for the development and introduction of biomarkers to the clinic and has first-rate sections on pre-analytical, analytical and post-analytical aspects of biomarker assessment and the clinical uses of biomarkers in cancer.

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The final part of the book covers bioinformatics and regulatory aspects of proteomics. Chapter 10 provides a useful overview on efforts to annotate the human proteome, references useful data resources and, importantly, highlights the need and global initiatives for standardising the reporting and storage of proteomic information from different sources. The final chapter deals with regulatory issues in the co-development of drugs and proteomic tests. It includes the role of the Food and Drug Administration FDA in regulating the use of proteomics in cancer therapy and covers issues of target characterisation, intended use and indication for use, method and operation standardisation and the importance of study design.

Despite the reservations outlined above, the book provides a broad account of the area of cancer proteomics and adequately covers issues relevant to the use of proteomic strategies in clinical research.

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There are useful reviews of different methodologies, work in different cancer types, on biomarker development and clinical use and on bioinformatics and regulatory aspects of proteomics. The book would be of interest to clinicians and basic cancer researchers alike who are already involved in, or who are considering the use of proteomics in their work.

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Cancer proteomics: from bench to bedside?

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