Acoustic Characterization of Contrast Agents for Medical Ultrasound Imaging

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    A Visual Exploration of Every completed email in the law and events: In vitro B-mode images are generated using a medical ultrasound scanner by applying a nonconventional signal processing technique that is suitable to detect polymeric bubbles and based on the combination of multipulse excitation and chirp coding. Supplemental Content Full text links. National Center for Biotechnology Information , U. Federal Government the danger.

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    It has there complex to switch on the economy's general maps. Contrast-enhanced ultrasound imaging To enhance the visibility of the blood pool, ultrasound contrast agents have been developed, enabling the visualization of the perfusion of organs. The typical UCA is composed of a suspension of microbubbles radius micrometer which are coated with a phospholipid, albumin or polymer shell to prevent the bubble from quickly dissolving in the blood.

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    The key feature of ultrasound contrast agent microbubbles is their nonlinear response. Dynamics of coated bubbles The nonlinear dynamics of coated microbubbles used in contrast-enhanced ultrasound imaging is complex due to the nonlinear viscoelastic behavior of the shell material. A detailed study of individual bubbles, isolated by the use of optical tweezers, revealed a frequency and pressure dependence, which can be exploited to improve pulse-inversion and power-modulation contrast imaging techniques.

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    Contrast agents for medical ultrasound imaging is a field of growing interest. A large amount of literature has been published on the medical applications of such. Acoustic characterization of contrast agents for medical ultrasound imaging. The Journal of the Acoustical Society of America , (); Nycomed's ultrasound contrast agent NC has been investigated by in vitro acoustic.

    Optical and acoustical characterization Bubbles are driven by a acoustic pressure pulse, leading to pulsations, which can be recorded with a high-speed camera. The bubble oscillations lead to a secondary acoustic response, or echo, which can be picked up in the far-field.

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    We characterize the nonlinear bubble behavior by a combined measurement of the optical and acoustical response, which lead to an improved physical insight of contrast-enhanced medical ultrasound imaging. Resonances of coated bubbles The response of a coated bubble to the driving pressure pulse is governed by its resonant behavior.

    From the resonance curves we deduce the viscoelastic properties of the shell material at MHz driving frequencies.